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DQ3_07 Assignment Example | Topics and Well Written Essays - 250 words

DQ3_07 - Assignment Example started in 1948 and led among 5209 grown-up members in Framingham, Massachusetts, has helped to give a signif...

Tuesday, August 25, 2020

DQ3_07 Assignment Example | Topics and Well Written Essays - 250 words

DQ3_07 - Assignment Example started in 1948 and led among 5209 grown-up members in Framingham, Massachusetts, has helped to give a significant part of the now realized information with respect to coronary illness. The Framingham Heart Study has demonstrated as a remarkable work with respect to its degree, span, and data. The investigation assisted with giving comprehension because of way of life, ecological elements and legacy on heart wellbeing. The investigation gave the birthplace of the term ‘risk factor’ (FHS, 2015). The examination assisted with distinguishing major CVD chance factors, for example, hypertension, smoking, corpulence, high blood cholesterol, diabetes, and physical dormancy. Preceding the beginning of the investigation, surgeons had little information according to the avoidance of heart sicknesses. The examination assisted with demonstrating the need of weight the board, a sound eating regimen, and standard exercise in forestalling heart infections. The examination additionally helped to uncover the distinctions in the danger of heart sicknesses among people. The examination has extended to envelop research on the job of hereditary qualities in adding to

Saturday, August 22, 2020

Research Proposal on Inhalants and Children

Research Proposal on Inhalants and Children Research Proposal on Inhalants and Children Area 1 Presentation This paper contains a proposition on the examination about the inhalants use and its concern and how it influences kids. The examination question to be addressed is the reason are kids the most defenseless gathering since they are the most influenced by the utilization of the inhalants? In numerous social orders inhalants have been influencing the little youngsters and not the elderly folks individuals in the general public. There are numerous reasons with regards to why the kids take part in the use of the inhalants. These reasons can be characterized through numerous ways. Inhalants are normally utilized by the teenagers that later alumni and start utilizing different types of hard medications in the general public. The explanation is on the grounds that they are promptly accessible in the social orders. THE LITERATURE REVIEW The examination paper ought to be founded on the investigation of various social orders and why they participate in the use of the inhalants. There are various quantities of items which are utilized at home and in the social settings which are normally known as the inhalants. These items influence thinking limits about the kids and their public activities in the genuine sense. A large portion of the inhalants which are utilized today involve of items which are utilized on consistent schedule, for example, the paints, stick, liquid utilized for cooking, butane, fuel, shoe clean and mist concentrates. These are the items which are promptly found in the homes and which influence the public activities of the youngsters. Actually, the youngsters misuse the inhalants without the information that these medications have an impact in their lives. The writing survey ought to likewise have the option to cover the inclining factors which lead the little youngsters to manhandle the medications. A portion of the reasons why the little youngsters participate in the use of the medications incorporate the friend pressure in their homes, impact from guardians who misuse different sorts of medications and furthermore stress. These elements ought to be shrouded in the exploration paper and furthermore be dissected in a consecutive way in order to upgrade the training of the medication contribution by the small kids. Truly, inhalant maltreatment has social, societies and otherworldly effect on the clients. The clients are commonly the kids and they are later influenced in their lives. In this manner, the guardians have the order to instruct their youngsters in order to keep them from participating in hazardous exercises. It is additionally a matter of general worry to the remainder of the general public. Explicit POSITION The particular situation of the exploration ought to be equipped towards helping the kids to comprehend that medications are not significant piece of their public activities. The paper ought to likewise contain measures which are intended to guarantee that the kids have been discouraged from the utilization of the medications. A portion of the measures which are referenced incorporate the capacity to be instructed by their folks at homes and both in their schools. Hazard factors which lead the youngsters to manhandle the inhalants ought to likewise be referenced in this segment. This is on the grounds that hazard factors contribute a great deal in warmth of the social and the drawn out utilization of the inhalants. End The end part ought to contain the general synopsis of the paper regarding the negative effect of the medication use. It is a typical information that the utilization of the inhalants influences the ordinary conduct of an individual and furthermore reaches out to their wellbeing. This ought to be instructed to the kids to keep them from being occupied with the utilization of the inhalants. Inhalant maltreatment can open an individual to a few confusions which incorporate obstruction to ones social prosperity. One loses loved ones as they enjoy into inhalant maltreatment. This ought to likewise be forestalled in order to shield the kids from utilizing the medications. To summarize, the situation of the specialist on inhalant maltreatment ought to likewise be featured in this part. Segment TWO In this segment of the examination paper, the writing audit on the utilization of the inhalants will be dissected in a more profound setting. There are three subheadings which will be canvassed in this segment; one of the headings is the qualities of the abusers, their reliance and the examples wherein the kids use to manhandle the inhalants in the general public. So as to compose this data a few articles have been summed up to think of an obvious end result. This improves the general perspective on the inhalant utilization in the general public. The greater part of the discoveries in the exploration paper will reach an obvious end result that if inhalant use has been subdued at a beginning time, it tends to be forestalled and this will guarantee that there is a general public which is liberated from the inhalant maltreatment and use in the general public. Use PATTERNS There are numerous ways and examples which are utilized by small kids in order to get occupied with the use of the inhalants. A portion of the examples remember the utilization of the inhalants for the social circumstances. These social circumstances incorporate the companion impact between the ages of 6 to 14. By and by, transient secluded use is another example which is utilized by the youngsters who have a history in tranquilize misuse. Specifically, guardians who have a history in the utilization of medications and tobacco, incredibly impact the kids to begin utilizing the inhalants. The young stage is simply the interminable stage where the kids connect with themselves in the use of the inhalants. They should along these lines be kept from utilizing the medications at a beginning period since this prompts the presentation of more risks. Attributes OF THE ABUSERS There are numerous signs and side effects which are frequently used to test whether an individual uses an inhalant or not. A portion of the qualities which are depicted by all the inhalant clients incorporate the foul smell brought about by the use of various synthetic substances. Besides, this regularly influences the mouth and other basic body parts. Guardians should likewise be cautious when dealing with the instances of their kids since signs, for example, loss of hunger, nervousness and improvement of stress are an indication that the kids have drawn in themselves more profound into the inhalant utilization. In summation, the reliance of the youngsters to get the medications ought to likewise be secured. Because of the fundamental truth that inhalants are found at home, they are regularly free. This is on the grounds that kids can have a simple access to them and consequently use them without their parent’s information. Likewise, kids regularly get the inhalants from their folks and their companions. Kids ought to be hindered from the utilization of the medications in order to guarantee that they are sheltered. This additionally responds to the fundamental inquiry for what reason are the kids the most powerless gathering. The explanation is basic, they generally get the medications openly. On the off chance that you need a custom research proposition on Inhalants and Children don't hesitate to find support with composing an exploration proposition for PhD or Masters paper from our exceptionally qualified scholastic authors.

Saturday, August 8, 2020

How to Answer Are You Willing to Relocate in an Interview

How to Answer “Are You Willing to Relocate” in an Interview Job interviews can be such a hassle!Interview starts the moment you enter the building/office, which basically means you can mess up before even opening your mouth.The interviewers will be observing your outfit, punctuality, handshake and body language. All of this before you even get to the actual questions.And when you do get to this part, mess up chances multiply by hundred.You already conducted research and thought potential questions through. In addition to the preparation, you will strive to preserve a smiling and relaxed image throughout this whole process.Everything matters.One of the trickiest questions you could face is a question regarding possible relocation, hence, whether you would be willing to move to another place for work.I remember the first time I got asked this in an interview. I was surprised and didn’t know what to say at first! I presumed my readiness to do an interview for a company based in another country was self-explanatory.It was only later I realized that nothing is self-explanatory in the recruiting process.Sometimes, the interviewer is not really that interested in the actual answer to this question. He/she is a lot more interested to test your reaction and see how (rather than what) you’ll answer.The ‘relocation’ question falls into the category of such ‘test’ questions.In other words: a company will not always want to move you immediately or maybe even ever but they will, frequently, ask this question to test your flexibility and dedication.And being so common and tricky, you may want to keep this question in mind while preparing for that interview you have coming up. Start by remembering this general wisdom: it is usually not so much what, but rather how you say something. And when it comes to communicating your thoughts properly, preparation is essential.PREPARATION FOR THE INTERVIEWPersonally, I am a huge fan of the spontaneous approach. Unfortunately, I learned the hard way that an interview isn’t a good plac e to test ones creativity.If you want to do well, you better get yourself as prepared as possible for literally everything.And I mean it: case studies, company’s history, researching possible interviewers, searching for people you may know in the company.Last but not least: reflect thoroughly on all questions which could potentially come up, hence, think of potential answers you could provide.It is a bad feeling going back and thinking about all things you could have said differently/better. Therefore, it is worth investing a minute to think about the actual thing you wish to say.And this also refers to the question on potential relocation.“Are you willing to relocate for this job?” Well, the first question you should ask yourself (before the interview) is: Are you?The crucial part of the preparation is clearing up the situation inside your head and being honest about what you can and cannot do.If the answer is ‘depends’, you will still want to be very concrete about facto rs your decision depends on.After you are clear about what your answer should be, you may want to think about the manner in which you wish to convey your decision.As said, the interviewer may simply want to test your motivation for a job in that particular company. Reason more to approach this question with diligence.Finally, it is crucial that you answer honestly even if you decide to cover the essence with a bit of curtsy and small talk. Dishonesty in an interview rarely pays off in the long run.DIFFERENT SCENARIOS AND DIFFERENT ANSWERSSo, after you decided on what your answer essentially would be, take a look at a few possible answers for several different scenarios:You want to and can moveSuper easy, right?Yes, the decision itself could have been an easy one to make but you will still want to consider your exact answer.Let us imagine you are a young professional with some international experience, no strings attached and perfectly ready and eager to move for a job.That is all go od and the company will certainly look forward to hearing your affirmative reply.Nevertheless, note that form of this reply can be more significant than its exact content.You can say: “Sure, absolutely, I can leave as soon as tomorrow! Money-wise it could a bit of an issue but if you could help with that, all should be good.”You could say something like this…but you shouldn’t. You are not preparing to head off for a school trip but to move to another city or country, hence, make a huge life decision.You will want to appear as a professional, who is aware of the significance of this step and who took all relevant circumstances into account.Therefore, your answer should be something like this:“This would be an amazing opportunity, both professionally and privately. Thank you for taking me into account. As you know, I do, already, have some prior international experience and I certainly enjoy changes which is why I am confident this transition will run smoothly. Naturally, th ere are a lot of things that should be discussed and decided in advance which is why I would look forward to an in-depth conversation on this topic.”See the difference?Yes, well, the interviewer will see it too.It doesn’t necessarily mean that a first answer will trigger bad consequences but it may leave you looking incompetent, unserious or childish. And I presume this is not what you are aiming at.In this scenario, it is crucial to think the relocation process through, hence, to come up with potential questions for an interviewer.And don’t worry; asking questions will not make you appear annoying but rather mature, professional and grounded.I know that the sole possibility of relocation may be extremely exciting but sometimes it is better to seem less enthusiastic if this makes you appear more professional. You could move, but only for a limited amount of timeOk, this one is a bit trickier but if this is your decision, you should be able to present it as professional as poss ible.Here, the key is to present your reasons, grounds, and limitations as clear and as structured as possible.What can you, what can’t you do? For how long or how far would you be able to move? Be concrete.Following that, you should be able to provide reasons for such an answer. It is perfectly fine to be limited by personal reasons but notes that you will have to provide some justification for your answer.Whether this is family, children, personal attachment or the fact you recently bought a house you are still paying off… It is all fine but be prepared to explain it.Your answer could be something like this:“Thank you so much for taking me into account for this amazing opportunity. Although I would love to accept it immediately, I must first warn you about my limitations. I would be glad to relocate; however, my relocation couldn’t last for more than one year. As you probably know, I am always opened for remote projects and my family is used to this but a permanent relocat ion, unfortunately, just isn’t an option for us. If a short-term relocation would be an option, I would definitely love to hear more about it.”Polite but on point.State your grounds while remaining honest about your limitations and preferences.You are unsure about the relocationCan “maybe” be an answer to the relocation question?The answer is yes, but you have to make sure you say it properly.You will not want to lose a good opportunity for appearing indecisive.Sometimes, a company just wants to test you, not necessarily relocate you.Nevertheless, this is a potentially major life decision and it is perfectly fine if you need more time and/or information.You will need to create more playgrounds for yourself, which means, no straightforward answers at first. You will want to demonstrate potential readiness to move while learning more about the concrete opportunity.What you should investigate are points, such as duration, development opportunities, relocation package and when e xactly they would want/need you there.Before discussing these tough questions, you should try to appear enthusiastic while remaining slightly vague with a definite answer.You could try something like this:“This is a great opportunity for which I feel I would be a great fit. Thank you for taking me into account. I do enjoy working in this area but if relocation creates more room for career advancement and growth, I would definitely consider it.”If the answer is ‘maybe’ due to family/personal commitments, you should simply put it like that:“This is a great opportunity and although I’d love to accept it on the spot, I would have to discuss this with my family first. This would be a major life change for all of us, which is why I really must involve them in providing a final decision.”‘Maybe’ doesn’t have to appear indecisive.It can simply mean that you need more time, space and/or information and if you ask for it nicely, companies will generally be happy to provide you with whatever you need.You do not want to moveSaying “no” doesn’t mean you’ll get fired or that you won’t be hired in the first place.So try not to freak out in advance.Also, know that even though saying ‘no’ may cost you this particular job (e.g. relocation is necessary), there are certainly ways to say it and still appear motivated by the position.Relocation is a huge step and it involves major life changes. It is perfectly fine if you decide to pass and in fact, nobody should take for granted you’ll agree.Speaking of which, you most certainly shouldn’t ever say yes if you don’t mean it. In the long run, nobody will profit from you lying.Therefore, a ‘no’ can be fine, but it very much matters how you say it. You surely don’t want to say:“Hell no. I’m sorry but I have a life here” and end the conversation.No. You should always start by saying thank you and saying that you know what a fantastic opportunity this is. Following this, you should expl ain yourself and reasons why you truly cannot consider moving.If you consider your reasons to be too small or perhaps, unprofessional (e.g. short relationship you started recently but are really enjoying), try to come up with additional ones or just remain vague: e.g. say you have personal reasons for being unable to relocate at this point.Chances are that an interviewer will prefer such an answer over your history of relationships or the whole story about your very close relationship with your parents.Try to judge your reasons from the third-party perspective and if the story doesn’t seem too convincing, try to work your way around it without giving away too many details.Finally, do emphasize your interest in the company, position and work you would be doing if hired. Say that you would really appreciate being given a chance on that location if such a possibility exists.Finally, do try leaving relocation door slightly open (if only in theory).Say that you wouldn’t exclude reloc ation completely, especially if such an opportunity entails more chances for development and growth.Even if you truly cannot imagine this happening, say something in this tone.Very subtle and cautious but try not to be too exclusive. Honesty is perfectly fine and even desirable, but this is simply a smart way to play it.You initiate the moveChances are that this question will not really pop up in this scenario since it will be you initiating the relocation, hence, your willingness will be pretty obvious.Still, as in all other scenarios, you should be careful how you approach this issue. Especially in cases where you are on an interview or already working in one location while wanting to be considered for a relocation.Frequently, this will be taken as a health initiative and will be perfectly fine.Nevertheless, this attempt may still come across as dissatisfaction with a job at a current location and if so, the employer may not really like this.Especially in cases where a relocation includes a significant salary increase or you decide to relocate so that you could boost your promotion chances, it is important to be smart about putting those motives into words.It is probably better if you start with motives, such as challenging environment, learning and development opportunities, life change, different cultural experience, personal reasons (friends or family in the other location) etc.More specific grounds should follow only after this general introduction. At this point, you can mention something like better advancement opportunities or relocation as a condition for promotion etc.In many companies nowadays, it is perfectly fine and even admirable to initiate the relocation.Still, try not to offend anyone, skip the money/salary factors and finally, emphasize your overall satisfaction with the current location and position.Those who dear win, but you will want to avoid unnecessary risks.ADDITIONAL QUESTIONS WHICH COULD COME UPEven if you state your reasons perfec tly well and eloquent, be aware that an interviewer may keep coming up after you. This is simply something they do and you will have to deal with it.Bearing this in mind, it may be useful to think some potential additional questions through:Q1: Why don’t you want to move? It’s a great opportunity.A1: It truly is. If my situation would be even slightly different, I’d jump right on it. Nevertheless, for reasons I already explained earlier, I just can’t accept it. If something changes in the future, I would be more than willing to revisit this topic again.Q2: What if we improved the deal? (e.g. pay for the entire move; offer incentives such as raise, promotion, moving bonus; help a spouse with finding a job).A2: Well, I can’t claim this offer isn’t tempting. Would you mind giving me some time (e.g. day, two, three) to think about it? I would still have to discuss this new package/offer with my family. I am not promising anything, but I would appreciate a chance to reconside r the whole deal with a clear head.Q3: We’re eliminating your position here regardless of your relocation. Do you really want to lose your job?A3: That is truly misfortunate given a terrific experience I had in this company. Is there a chance a could get some additional time to try to come up with the best solution, satisfactory for both sides?Q4: How soon could you move here and start working for us?A4: Given my excitement regarding this opportunity, I would love to be there as soon as possible, that is, as soon as you want me. Naturally, there are some technical obstacles to me being there immediately which is why I’d say I could be available in… (Provide a minimum time frame). With the purpose of making this whole process smoother and faster, I propose we discuss details of relocation in more detail.POINTS TO EMPHASIZERegardless of your answer and the explanation you provide, there are a few things which should always be emphasized, and a few tricks which will provide you w ith a kind of a safety net.Talk about the position with enthusiasm, regardless of whether or not you are willing to move!We already discussed this. The relocation question may be just a test or a remote possibility. If you really want the job, make sure you let it show.Be honest with what you want and don’t want: this will prevent future issues if you get the position.Honesty is essential. You may be tempted to lie in an interview because you really want this job but if moving really isn’t an option, do say it.It will be so much harder to leave the company after already getting the job and you could also risk some bad professional reputation for being insincere, which is never a good outcome.Emphasize your sincerity for wanting to work in the company.The same as with the first point. Make sure to make the company aware of your interest in it. Make sure they know how much you would appreciate being given an opportunity.Ask questions about relocation to see if this is a right move for you.This one is important. You may be super excited to hit the road and move but asking questions will demonstrate an overall professionalism. THINGS YOU SHOULD AVOID SAYINGJust as there are some key points which should be emphasized, there are a lot more phrases and things you should simply never, ever say.I will try to enlist some of these below so do make sure to remember them for these (or similar) phrases can be a career killer:“Will I get paid more if I decide to do it?”I think it is perfectly clear this is a major no go.As previously mentioned, you should be very cautious when discussing money/salary issues.Being this opened about it is plain bad and will most definitely be unattractive for a person talking to you.Don’t just say ‘no’ if you are unable to move.As with anything else, simple ‘no’ is rarely a satisfactory answer. In an interview, almost never. A plain ‘no’, will almost inevitably put you out of the run for a position.Unless you really don†™t care, try putting some effort into explaining grounds for your decision.Do not definitively confirm if there are uncertainties about your ability to transfer.Again, honesty and transparency.I know you want to take the deal and show your absolute readiness but being honest will frequently be accepted just as well.On the other hand, lying and changing previously given statements almost never will.Pick up the courage and explain the situation.Trust me, this is way better than stressing out about letting interviewers know things you said no longer stand.Don’t be too vague / give answers which don’t provide any real informationTalk business. It’s ok not to reveal absolutely everything but do give some flesh to your story. Interviewers don’t like being fooled around. Saying things like:“I am not sure this is the right moment for me to take this step/ I am not sure this would be possible for me at this point” most probably will not come across well.Try not to waste other peo ple time by providing general statements.YOU ARE NOW READY…With these tips, you should be perfectly fine to answer the relocation question.And indeed, any answer can be a good one, as long as you put it nicely.It is a difficult question because relocation itself is a difficult and a significant move.Make sure you get your head, facts, and goals straight and provide a definite answer only after you are sure you know what you want.Stay polite, clear and humble and remember: you got this!

Saturday, May 23, 2020

Chapter Analysis Harry Potter - 985 Words

Audrey Loeffler Fields English period 1 March 9, 2014 Forget Harry Potter, This is the Boy Who Lived Pi is an incredible individual. He went on an inconceivable journey that changed him mentally. There was no way he would come back the as the same person. After going through a shipwreck, he refuses to believe that he might really be stranded. When he acknowledges that he really is lost, Pi kills for the first time for the sake of survival. His physical and religious limits are tested immensely and it transforms him forever. Pi has a definite reason to go on this journey. He explains his shock upon discovering the sinking ship, â€Å"I couldn’t believe my eyes. What was this water doing here?†¦ Down there was where my family was† (Martel 129). It was that he had no choice. Pi’s life was thrown head first into a shipwreck, his happiness ground to a halt. He lost his family in his call to adventure. He has nothing to lose, until his shock drives him to near insanity, â€Å"Ravi was right. Truly I was to be the next goat. I had a wet, trembling, half-drowned, heaving and coughing three-year-old adult Bengal tiger in my lifeboat† (Martel 124). Shock is a powerful thing. Pi was so stunned he did not realize that he was helping a tiger into his lifeboat until it was too late. There is now absolutely no way Pi will not have an adventure. Staying alive is adventure enough. That is not to say Pi wants an adventure. Pi’s wants, his desires for a normal life with his family has clashed with theShow MoreRelatedThe Way Of The World Essay1580 Words   |  7 Pagesbecomes more fragmented in novels. The Following four works; â€Å"Harry Potter and the prisoner of Azkaban†(1999), â€Å"The David Copperfield†(1850), â€Å"The Prime of Miss Jean Brodie†(1961) and â€Å"Dead Poets society†(1989) are defined as the literary genre ‘Bildungsroman’ in different Medias. Each of the works has different analysis of Bildungsroman as the methods of maturity. 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Tuesday, May 12, 2020

Wallis Simpson Life, Legacy, Marriage to Edward VIII

Wallis Simpson (born Bessie Wallis Wakefield; 19 June 1896—24 April 1986) was an American socialite who gained notoriety for her relationship with Edward VIII. Their relationship caused a constitutional crisis that ultimately led to Edward’s abdication. Fast Facts: Wallis Simpson Known For: Socialite whose relationship with Edward VIII caused a scandal and led Edward to abdicate the British throne.Given Name:  Bessie Wallis WarfieldBorn: June 19, 1896 in Blue Ridge Summit, PennsylvaniaDied: April 24, 1986 in Paris, FranceSpouses: Earl Winfield Spencer, Jr. (m. 1916-1927), Ernest Aldrich Simpson (m. 1928-1937), Edward VIII aka Prince Edward, Duke of Windsor (m. 1937-1972) Early Life Wallis was born in Blue Ridge Summit, Pennsylvania, a popular resort town near the Maryland border. Her father, Teackle Wallis Warfield, was the son of a wealthy Baltimore flour merchant, and her mother, Alice Montague, was a stockbroker’s daughter. Although Wallis always claimed her parents married in June 1895, parish records show that they weren’t married until November 1895—meaning that Wallis was conceived out of wedlock, considered a big scandal at the time. Teackle Warfield died in November 1896, when Wallis was only five months old. His death left Wallis and her mother dependent first on Teackles brother, then on Alice’s sister. Walliss mother Alice remarried in 1908 to a prominent Democratic politician. When Wallis was in her teens, she attended an elite all-girls school in Maryland, where she excelled academically and gained a reputation for her polished style. First Marriages In 1916, Wallis met Earl Winfield Spencer, Jr., a pilot with the U.S. Navy. They married later that year. From the beginning, however, their relationship was strained, in large part due to Spencer’s heavy drinking. By 1920, they entered an on-and-off period of temporary separations, and Wallis had at least one affair (with Argentine diplomat, Felipe de Espil). The couple traveled overseas in 1924, and Wallis spent most of the year in China; her exploits there were the subject of much rumor and speculation in later years, though little was ever confirmed. The Spencers’ divorce was finalized in 1927, at which point Wallis had already become romantically involved with Ernest Aldrich Simpson, a shipping magnate. Simpson divorced his first wife, with whom he had a daughter, to marry Wallis in 1928. The Simpsons set up a house in the wealthy London neighborhood of Mayfair. In 1929, Wallis returned to America to be with her dying mother. Although Walliss investments were destroyed in the Wall Street Crash of 1929, Simpson’s shipping business was still booming, and Wallis returned to a comfortable and wealthy life. However, the couple soon began to live beyond their means, and financial difficulties loomed. Relationship with the Prince Through a friend, Wallis met Edward, Prince of Wales, in 1931. After crossing paths for a few years at house parties, Wallis and Edward entered a romantic and sexual relationship in 1934. Edward abandoned his previous mistresses and the relationship deepened. He even introduced Wallis to his parents, which caused a huge scandal, seeing as divorced people were not typically welcome at court. On January 20, 1936, King George V died and Edward ascended to the throne as Edward VIII. It quickly became clear that Wallis and Edward intended to marry, as she was already in the process of divorcing Simpson on the grounds that he had committed adultery. This presented several problems. From a social and moral perspective, Wallis was not considered a suitable consort. Even more pressingly, from a religious perspective, her marriage to Edward was constitutionally forbidden, since the the monarch is the head of the Church of England and the Church forbade remarriage of divorced persons. Abdication of Edward VIII By the end of 1936, Wallis’s relationship with the king had become public knowledge, and she managed to flee to her friends’ home in France just ahead of the media frenzy. Despite pressure on all sides, Edward refused to give up his relationship Wallis, and instead chose to abdicate the throne in the face of a constitutional crisis. He officially abdicated on December 10, 1936, and his brother became George VI. Edward departed for Austria, where he waited out the end of Wallis’s divorce proceedings. Wallis and Edward married on June 3, 1937—the same day as Edwards late father’s birthday. No members of the royal family attended. Edward had become the Duke of Windsor upon his brother’s accession, and while Wallis was permitted the title of â€Å"Duchess of Windsor† upon their marriage, the royal family refused to let her share in the â€Å"Royal Highness† style. Duchess of Windsor Wallis, along with Edward, was soon suspected of being a Nazi sympathizer—not a far jump, since the couple visited Germany and met with Hitler in 1937. Intelligence files at the time also suspected Wallis of carrying on an affair with at least one high-ranking Nazi. The couple fled their French home to Spain, where they were hosted by a pro-German banker, then to the Bahamas, where Edward was sent to perform the duties of governor. Wallis worked with the Red Cross and devoted time to charitable causes while in the Bahamas. However, her private papers revealed a deep disdain for the country and its people, and the couple’s Nazi connections continued to come to light. The couple returned to France after the war and lived socially; their relationship may have deteriorated over the years. Wallis Simpson published her memoirs in 1956, reportedly editing and rewriting her own history to portray herself in a more flattering light. Later Life and Death The Duke of Windsor died of cancer in 1972, and Wallis reportedly had a breakdown at his funeral. By this time, she was suffering from dementia and other health problems, and her lawyer, Suzanne Blum, took advantage of Wallis’s state to enrich herself and her friends. By 1980, Wallis’s health had declined to the point where she could no longer speak. On April 24, 1986, Wallis Simpson died in Paris. Her funeral was attended by several members of the royal family, and much of her estate was, surprisingly, left to charity. Her legacy remains a complicated one—an ambitious and glamorous woman whose great romance led to great losses. Sources Higham, Charles. The Duchess of Windsor: The Secret Life. McGraw-Hill, 1988.King, Greg. The Duchess of Windsor: The Uncommon Life of Wallis Simpson. Citadel, 2011.â€Å"Wallis Warfied, Duchess of Windsor. Encyclopaedia Brittanica, https://www.britannica.com/biography/Wallis-Warfield-duchess-of-Windsor.

Wednesday, May 6, 2020

#15 Synthesis of Ethyl Salicylate from Salicylic Acid Free Essays

#15 Synthesis of Ethyl Salicylate from Salicylic Acid ____________________________________________________________ _______________ Purpose: Salicylic acid is converted to the liquid ethyl salicylate by addition of ethanol. Yields of salicylic acid (week 1) and ethyl salicylate will be found, as well as the overall yield of the 2-step conversion of acetyl salicylic acid to ethyl salicylate. Introduction: Esters are formed from the reaction of acids and alcohols: O O || || R-C-OH + HO-R’ R-C-OR’ + H2O cid alcohol ester water The pleasant smelling oil of ethyl salicylate is made by reacting salicylic acid (week 1) with excess ethanol. We will write a custom essay sample on #15 Synthesis of Ethyl Salicylate from Salicylic Acid or any similar topic only for you Order Now An acid catalyst is also needed. salicylic acid (SA) ethanol ethyl salicylate (ES) The overall yield is determined from multiplying yields of the two reactions: 1. ASA + HCl(aq) SA and 2. SA + ethanol ES + water Apparatus The reaction takes place by refluxing (gentle boiling) in a 100-mL round bottom flask. This time the ice-cooled condenser is essential, otherwise the ethanol reactant (b. . 79? C) would evaporate before the reaction was over. Melting points of acetyl salicylic acid and salicylic acid (dried from week 1) are taken with MelTemp devices. If you have never used one your instructor will demonstrate. MelTemp C OH O OH H OC H2CH3 H + C OH O + OCH2CH3 + H2O2 Procedure Part A: Esterification of Salicylic Acid with Ethanol 1. Before starting remove a spatulaful (that will be 0. 1 g) of SA (salicylic acid) and place in a labeled plastic vial to use for melting points. 2. In a 100 mL round bottom flask, mix at least 5 g dry salicylic acid (0. 43 mol) with 20 mL 100% ethanol. The salicylic acid should be weighed out to two decimal places and recorded on the data sheet. The alcohol is in excess. It can be poured from a graduated cylinder, and should not be scaled down. Note: Use more salicylic acid if you have more from the first week. You should have between 7 and 8 g. Adjust amount of ethanol accordingly, say to 30 mL. 3. Add approximately 1/2 gram of boric acid catalyst that we use as a substitute for concentrated sulfuric acid in this particular esterification. 4. Place entire assembly on a hot plate and heat until the alcohol is boiling. A setting of around 3 on the hot plate can be tried and then adjusted up or down as needed. You may need to add more ice. Note: While the refluxing is taking place, you can work on Part B, in which the materials you have already made are characterized by taking their melting points. 5. Reflux for a minimum of 1 hour and 30 minutes or longer as time allows. Cool until the flask is no longer hot, then in an ice bath, until the mixture is at room temperature. Transfer to a clean separatory funnel. 6. Add 10 mL 2M NaOH(aq) . The mixture turns milky as approximately 2-3 mL of ester appears at once as an insoluble bottom layer. Ethyl salicylate is an oily liquid with a density of 1. 1 g/mL. Wait a few minutes until the cloudy emulsion begins to clear up. You can estimate the yield by marking the funnel and measuring an equal volume of water. Record this. You will probably get about 1/2 mL for every 1 gram of salicylic acid. 7. You should be able to recover about 1. 5 mL of the ester oil by separating the layers using a separatory funnel. Allow the bottom layer to pour into a vial. This layer contains mostly ethyl salicylate and should have a very pleasant odor, something like wintergreen. It will also include a little NaOH solution and thus will not be clear and sparkling. If you have enough liquid you can attempt the next step. 8. Dry by mixing with a small amount of anhydrous magnesium sulfate. See your instructor to get help with this. Pour off the clear ethyl salicylate. 3 Part B: Melting Points 1. Measure melting points of the dry acetyl salicylic acid and the salicylic acid using the small samples reserved for this purpose. Record on data sheet and compare with literature values. Part C: Yields 1. The 50 aspirin tablets contained 16. 25 g ASA. To estimate yields in your next 2 reactions, assume the wet ASA you used contained 12 g ASA. Then from the mass of dry salicylic acid obtained find the yield of salicylic acid. 2. Convert the volume of ethyl salycilate to grams using the density, 1. 1 g/mL. Record. Estimate yield of ethyl salicylate from salicylic acid and record, retaining just 2 significant figures. 3. Find the overall yield of the two-step process: Step 1: Acetyl salicylic acid (ASA) to salicylic acid (SA) Step 2: Salicylic acid (SA) to ethyl salicylate (ES)4 Data and Results (yield of ethyl salicylate) Name(s) ____________________________________________________________ ____ Part B: Melting Points Compound Measured Melting Point (? C) Literature Value (? C) Acetyl Salicylic Acid 134 – 135 Salicylic Acid 158 – 160 Yields: Assuming ASA (from extraction of 50 aspirin tablets) = 12 g SA (from hydrolysis of ASA) ______ g Reactant SA esterified: ______ (usually most of the amount above) Approximate volume of ethyl salicylate: _______ mL (density ES = 1. 1 g/mL) Mass ethyl salicylate ________g Maximum g SA: Maximum g ES: Enter amounts where indicated in the table below and find the yields. Reaction Reactant Product Mass Reactant (g) Mass Product (g) Maximum Mass Product (g) Actual Yield % ( 2 sig. figures) ASA SA 12 g ASA* g SA g SA SA ES g SA g ES g ES *Assuming 75% extraction yeild. Overall Yield for 2 steps (product of 2 yields above) : Questions: 1. Recalculate the overall yield for a three-step process including the 75% extraction. 2. The synthesis of a new drug may require as many as 30 steps, some of which produce much less than 90% yields. Comment on this (without doing any calculations). ____________________________________________________________ _______________5 Instructor’s Guide Ethyl Salicylate Part B: Melting Points Compound Measured Melting Point (? C) Literature Value (? C) Acetyl Salicylic Acid 134 134 – 135 Salicylic Acid 159 158 – 160 Yields: Assuming ASA (from extraction of 50 aspirin tablets) = 12 g SA (from hydrolysis of ASA) 7. 3 g Reactant SA esterified: 7. 0 g (usually most of the amount above) Approximate volume of ethyl salicylate: 3. 0 mL (density ES = 1. 1 g/mL) Mass ethyl salicylate 3. 3 g Maximum g SA: 10 g ASA x 1 mol ASA x 1 mol SA x 138 g SA = 9. 2 g SA 180 g ASA 1 mol ASA 1 mol SA Maximum g ES: 7. g SA x 1 mol SA x 1 mol ES x 166 g ES = 8. 4 g ES 138 g SA 1 mol SA 1 mol ES Enter amounts where indicated in the table below and find the yields. Reaction Reactant Product Mass Reactant (g) Mass Product (g) Maximum Mass Product (g) Actual Yield % ( 2 sig. figures) ASA SA 12 g ASA* 9. 2 g SA 7. 3 g SA 79% SA ES 7. 0 g SA 8. 4 g ES 3. 3 g ES 39% *Assuming 75% extraction yeild. Overall Yield for 2 steps (product of 2 yields abo ve): 0. 79 x 0. 39 x 100 = 31% Questions: 1. Recalculate the overall yield for a three-step process including the 75% extraction. 2. The synthesis of a new drug may require as many as 30 steps, some of which produce much less than 90% yields. Comment on this (without doing any calculations). ____________________________________________________________ _______________ 1. Overall yield = 0. 75 x 0. 79 x 0. 39 x 100 = 23% 2. The yield would be very very small, making this an expensive process. 6 Instructor’s Guide Ethyl Salicylate(cont’d) Time: maximum Equipment and Materials: per group Items Number Comment stir/hot plates 1 stir bars 1 00-mL round bottom flasks 1 Weighing papers 1 pack per class Ice 50-mL graduates 1 Top loading balance 2 per class With power supply MelTemps 2 per class thermometer 2 per class For Meltemp m. p. tubes (closed) 50 per class 250-mL beakers 1 for water heating bath Microscale glass clamp 1 (yellow) ice-cooled condensers 1 Ring stand 1 Ring stand clamp 1 separatory funnels 1 boric acid 5 g per class antifungal agent spoon spatulas 1 100% ethanol 1 L per class 2 M NaOH 50 mL magnesium sulfate 10 g per class Epsom salts Safety glasses 1 per student Rubber gloves 1 box per class7 Ideas/ Information We make ethyl rather than methyl salicylate, because methanol is toxic. Under Part A. 3. Note: This experiment was designed to be done using household chemicals. Although Science in Motion can provide concentrated sulfuric acid, we have decided that it is too dangerous to handle. Under Part C. 1. Note: Repeated extractions were done in our lab. They all gave about 75% yields and about 12 g dry ASA. 2M NaOH solution could be prepared by adding solid NaOH to a volumetric flask and then diluting with distilled water to the mark on the flask. Molarity mol/L g NaOH for 1 L solution g NaOH 500 mL solution 2 80 40 How to cite #15 Synthesis of Ethyl Salicylate from Salicylic Acid, Papers

Saturday, May 2, 2020

COPD Symptoms and Impacts †Free Samples to Students

Question: Discuss about the COPD Symptoms and Impacts. Answer: Introduction This report aims to analyze the case study of Mr. Polaris who is a 62 year old man and has been diagnosed with chronic pulmonary disease. We have focused on two potential health concerns of the person related to the chronic pulmonary disease and have described why they are of potential concern. two topics regarding which the patient will be provided education by the registered nurse to facilitate self management of the chronic disease. The case have also focused and have provided justification regarding the two appropriate client education strategies that has to be delivered by the registered nurse for a better outcome of the patient. Moreover the actual aim of this report is to understand how self management of chronic diseases like chronic pulmonary disease can bring about improved outcomes in patients. COPD is normally an umbrella term that can be used to describe a variety of progressive lung diseases like chronic bronchitis, emphysema, refractory asthma and few forms of bronchiectasis. It has been reported that many people just overlook the increased breathlessness and the production of cough, as their normal signs of ageing. COPD can turn into adverse conditions if left untreated. George Polaris, is a 62 years old man, has been admitted into the emergency department with increase in shortness of breath. It was reported that he had fever with productive cough. On admission he was being first treated with type IV antibiotic, but later when he underwent a series of tests and examinations, it was found that he is having chronic pulmonary disease (COPD). After being discharged from the hospital he is being followed up at the local GP clinic. George reports to the registered nurse that he has had several episodes of respiratory distress where he was suffering from shor6ness of breath and cough on exertion. It has also been reported that before his admission to the hospital his cough and the respiratory problem turned worse. He has also reported that he had lost weights over the past few months. His current weight is 65 kg, with a height of 178 cms. Past medical history suggests that he had been suffering from respiratory distress for quite a long time. He had a history of gastro-esophageal reflux disease. George said that he was a smoker and generally smokes up to 20 cigarettes a day since he was 14 years old. According to the report George did not have any allergies or alcohol addiction. Current medications include Salbutamol 100 micrograms MDI, 2 puffs as required up to 4 times. Tiotropium 18mcg inhaled by the mouth and Esomeprazole magnesium 40mg. The vital signs includes that his body temperature is 36.7?, which indicates a normal body temperature. His blood pressure is 135/88 mm hg, which indicates a slight high pressure. His pulse beat is 100 beats / minute which indicates a normal heart beat and his respiratory has been reported to be 22 breaths / minutes. In the early stages of the disease, the symptoms may not be properly understood but can develop for years. The symptoms can be understood in the most advanced stages of the disease. The acute symptoms of the COPD are cough with a lot of mucous, shortness of breath. The case study shows that George has been suffering from respiratory problems, since a long time. The other symptom of COPD includes chest tightness and wheezing. Worsening of the COPD may give rise to Pneumonia. A patient having Pneumonia associated with COPD may show symptoms like the fever chills. The report shows that George was admitted with high fever to the hospital which can be linked with the general symptoms of Pneumonia (Asnaashari, Talaei, Haghighi, 2012). All the probable symptoms can be linked with the symptoms of George which indicates that he had been suffering from COPD. Emphysema can also be caused due to the COPD, due to which the air pressure in the alveoli increases. As a result the person feels short ness of breath which increases with time (Suissa, Patenaude, Lapi, Ernst, 2013). According to the case study, George is elderly and is a smoker. He works as a laborer in the construction company and is shortness of breath has worsened. The symptoms had indicated towards bronchitis and he needed a holistic care of approach to treat the conditions. Further as George had been a chain smoker, proper education regarding the ill effects of smoking might create awareness in him, and he might quit smoking. The two potential health concerns for the patient in this paper are mainly smoking and the inhalation of the noxious industrial agents. Smoking- Smoking can trigger flare ups in the COPD. Smoking damage the alveoli present in the lungs and the cell lining if the lungs. A COPD symptom will depend upon the condition of the lungs. The following case study reports that George was chain smoker. So it can be easily estimated that excessive smoking is one of the cause for a chronic obstructive pulmonary disease. It has been reported that people who smokes cigarettes or who suffer from passive smoking both have got a high risk of developing COPD (Donaldson Wedzicha, 2007). Client education strategies The above case study shows that George has been suffering from COPD for quite a long time, and then also he has not quit smoking. Smoking worsens the situation. Therefore it is very important for a registered nurse to help the client to quit smoking. A registered nurse should impart knowledge about the ill effects of smoking to the patient (Prevention, Chronic obstructive pulmonary disease among adults--United States, 2011. MMWR. , 2012). She should chalk out proper plans and would help the patient in all possible ways to quit smoking. The patient should be advised to avoid exposure to secondary smoke. The case study provides with the information that George has had several episodes of respiratory trouble (Sedeno, Nault, Hamd, Bourbeau, 2009). The patient can be taught how to use the bronchodilators and to report accordingly to the physician. The patient should be taught to take the prescribed medications that would help him to quit smoking, in due time and report to the doctor regu larly. A registered nurse can take up various strategies to impart knowledge to the patient. One such is providing information about the disease. A workshop can be conducted inside the health care setting taking the elderly patients and the pathophysiology of the disease can be demonstrated. The patients can be taught how to use the nebulizers and the bronchodilators. Self management of the techniques and the tools would help him to get rid of the problems. The patient can be taught the ways to quit smoking (Vestbo, et al., Adherence to inhaled therapy, mortality and hospital admission in COPD., 2009). Medications can be recommended that will help them to quit smoking. As the nurse is dealing with the elderly patients, care should be taken to provide a holistic care of approach to the patient. A patient can develop several self management strategies like eating of well balanced meals, use of the nicotine replacement therapies, eating of low calorie snacks, other stress relieving beverages can be had instead of cigarettes. There are special chewing gums that can help one to quit smoking, although everything should be taken after consulting with the caregiver. As sudden cessation of any kind of addiction without proper preparation may give rise to some adverse effects. A patient should in every way suppress the willingness to have cigarettes. Patient can look over the internet regarding the ill effects of nicotine. A registered nurse can provide proper education to the client regarding the prevention of the clinical condition (Roche, Chavannes, Miravitlles, 2013). A patient can be encouraged to take healthy foods; other beverages can be taken to relive stress other than cigarettes or other addictives. The strategies taken up by the registered nurse for ceasing the smoking habits in the patient would be appropriate as smoking can trigger flare ups in the COPD. Smoking damage the alveoli present in the lungs and the cell lining if the lungs. If the patient can control his smoking habit, it would not cure COPD, but the intensity of the symptoms will get reduced. Inhalation of the noxious industrial agents The case study provides with the idea that the patient works in a construction site, where he gets exposed to a number of chemical fumes and chemical allergens for a prolonged period of time can trigger COPD. Exposure to irritants on the job also makes an individual susceptible to COPD. Lung irritants such as grains, textiles, cement dusts or chemical fumes can trigger the symptom (Agust, et al., 2012). As discussed in the above section, about the two potential health concerns linked to the case study, the clients should be given education regarding the topics in order to self manage the conditions. The job of George also exposes him to dusts and irritants which can increase the intensity of the disease (Association, 2013). The client can be taught to use mask while working at the construction sides to avoid the lung irritants. The case study provides with the information that George has had several episodes of respiratory trouble (Sedeno, Nault, Hamd, Bourbeau, 2009). The patient can be asked to avoid the lung irritants, like paint or the households cleansers that emits chemical fumes. A patient should be taught the use of a humidifier. Humid air helps to loosen the mucus and the coughs of the upper airways (Effing et al., 2007).The patient can be taught how to use the bronchodilators and to report accordingly to the physician. The patient should be taught to take the prescribed m edications in due time and report to the doctor regularly. A registered nurse can provide proper education to the client regarding the prevention of the clinical condition (Roche, Chavannes, Miravitlles, 2013). The registered nurse can teach the patient to maintain a good hygiene like coughing and sneezing on a tissue, use of separate drinking glasses, washing of hand with warm soapy water or alcohol based gel during the unavailability of soap and water. As the nurse is dealing with the elderly patients, care should be taken to provide a holistic care of approach to the patient. Self management to avoid the obnoxious chemicals As per the education provided by the nurse the patient can avoid being exposed to harmful chemical fumes and other lung irritants for a prolonged period of time. The patient can carry face masks to prevent the allergens or should always try to use the mask while working on the construction site. The hydration of the body should be maintained. The patient should take enough fluids to maintain the electrolyte balance of the body. The patient should adhere to the medications that have been provided. Client should definitely use the bronchodilators as and when required. Since, the major problem that this client is facing is related to respiratory distress and cough. Therefore the patient care should be focused on how to prevent this. The knowledge of different exercises and the use of bronchodilators and the humiditors would definitely give relief from the incessant coughing and breathing trouble. Conclusion The above case study and its analysis have helped to provide knowledge about the different types of the chronic obstructive pulmonary diseases. According to the case study, George is elderly and is a smoker. He works as a laborer in the construction company and is shortness of breath has worsened. The symptoms had indicated towards bronchitis and he needed a holistic care of approach to treat the conditions. Since, the major problem that this client is facing is related to respiratory distress and cough. Therefore the patient care should be focused on how to prevent this. The knowledge of different exercises and the use of bronchodilators and the humidators would definitely help him to give relief from the incessant coughing and breathing trouble. Further as George had been a chain smoker, proper education regarding the ill effects of smoking might create awareness in him, and he might quit smoking. The normal pathophysiology and the symptoms have been linked with symptoms that George has displayed. From that it can be concluded that he might be suffering from chronic bronchitis. The essay had provided a vivid description of the interventions that can be taken up to impart knowledge to the patient, regarding the self management of the disease. Looking after the family background and his health condition, the topic aims to provide the possible strategies to impart knowledge to the patient and have concluded that this can be accomplished by setting up joint workshops, where different informations regarding the disease and different demonstrations to self manage the disease has to be demonstrated. Further it can be concluded that proper care, along with pharmacological therapies, good exercises and a proper discharge plan can improve the outcome of the patient and improve their way of living to some extent. References Agust, A., Edwards, L. D., Rennard, S. I., MacNee, W., Tal-Singer, R., Miller, B. E., et al. (2012). Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PloS one, , 7(5), e37483. Asnaashari, A. M., Talaei, A., Haghighi, M. B. (2012). Evaluation of psychological status in patients with asthma and COPD. Iranian Journal of Allergy, Asthma and Immunology, , 11(1), 65-71. Association, A. L. (2013). Trends in COPD (chronic bronchitis and emphysema). Morbidity and mortality,. 2. Barr, R. G., Celli, B. R., Mannino, D. M., Petty, T., Rennard, S. I., Sciurba, F. C., et al. (2009). Comorbidities, patient knowledge, and disease management in a national sample of patients with COPD. The American journal of medicine, , 122(4), 348-355. Bennett, A. V., Amtmann, D., Diehr, P., Patrick, D. L. (2012). omparison of 7-day recall and daily diary reports of COPD symptoms and impacts. Value in Health, , 15(3), 466-474. Bourbeau, J., Bartlett, S. J. (2009). Patient adherence in COPD. Thorax , 63(9), 831-838. De Marco, R., Pesce, G., Marcon, A., Accordini, S., Antonicelli, L., Bugiani, M., et al. (2013). The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population. PloS one, , 8(5), e62985. Donaldson, G. C., Wedzicha, J. A. (2007). COPD exacerbations 1: Epidemiology. Thorax , 61(2), 164-168. Effing, T., Monninkhof, E. M., Van der Valk, P. D., Van der Palen, J., Van Herwaarden, C. L., Partidge, M. R., et al. (2007). Self-management education for patients with chronic obstructive pulmonary disease. . Cochrane Database Syst Rev, , 4(4). Effing, T., Monninkhof, E. M., Van der Valk, P. D., Van der Palen, J., Van Herwaarden, C. L., Partidge, M. R., et al. (2007). Self-management education for patients with chronic obstructive pulmonary disease. . Cochrane Database Syst Rev, , 4(4). Prevention, C. f. (2012). Chronic obstructive pulmonary disease among adults--United States, 2011. MMWR. . Morbidity and mortality weekly report, , 61(46), 938. Roche, N., Chavannes, N. H., Miravitlles, M. (2013). COPD symptoms in the morning: impact, evaluation and management. . Respiratory research, , 14(1), 112. Sedeno, M. F., Nault, D., Hamd, D. H., Bourbeau, J. (2009). A self-management education program including an action plan for acute COPD exacerbations. COPD:. Journal of Chronic Obstructive Pulmonary Disease, , 6(5), 352-358. Seemungal, T., Harper-Owen, R., Bhowmik, A., Moric, I., Sanderson, G. M., Wedzicha, J. A. (2007). Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine, , 164(9), 1618-1623. Suissa, S., Patenaude, V., Lapi, F., Ernst, P. (2013). nhaled corticosteroids in COPD and the risk of serious pneumonia. Thorax, , 68(11), 1029-1036. Trappenburg, J. C., Koevoets, L., de Weert-van Oene, G. H., Monninkhof, E. M., Bourbeau, J., Troosters, T., et al. (2009). Action Plan to enhance self-management and early detection of exacerbations in COPD patients; a multicenter RCT. BMC Pulmonary Medicine, , 9(1), 52. Vestbo, J., Anderson, J. A., Calverley, P. M., Celli, B., Ferguson, G. T., Jenkins, C., et al. (2009). Adherence to inhaled therapy, mortality and hospital admission in COPD. thorax , 64(11), 939-943.